Clinical Efficacy of High-Frequency Deep Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression and the Predictive Role of Baseline Triglyceride Levels: A Randomized Sham-Controlled Trial.
Depression scores improved more with active deep rTMS than with sham stimulation over four weeks. A possible relationship with baseline triglycerides is exploratory and is not ready to guide treatment decisions.
Liu L, Wang J, Wu Z, Wang J, Li N, Wang M.
Clinical EEG and neuroscience · Publication date: 2026-09-10
Added to site: 2026-09-11
DOI: 10.1177/15500594261487817
First-publication date from the authoritative indexed record.
- Modalities
- TMS
- Clinical focus
- Depression, Personalization
- Population
- Patients with moderate-to-severe depressive disorder
- Sample
- 80 participants; 40 active and 40 sham
- Intervention / method
- Twenty high-frequency deep-rTMS sessions over four weeks
- Comparator
- Sham stimulation
Clinician summary
The primary HAMD-17 change favored active treatment. Higher baseline fasting triglycerides were associated with greater improvement, with a stronger association in the active arm.
How to interpret the findings
The abstract does not provide effect sizes, remission or response rates, adverse-event counts, follow-up beyond treatment, or external validation of triglycerides as a predictive biomarker.
Equipment and disclosures
High-frequency deep rTMS was described; coil design and commercial system were not verified from the abstract.
Funding and competing-interest disclosures were not verified from the reviewed abstract.
Related evidence
Compare findings from the same clinical area, including mixed results.
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- Identifying poor responders to repetitive transcranial magnetic stimulation using structural brain networks. · Positive with limitations
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- TMS-Evoked Cortical Reactivity Signatures as a Multidimensional Biomarker of Depression: A TMS-EEG Meta-Analysis from Diagnosis to Prognosis. · Positive with limitations
- The effects of cognitive-behavioural therapy (CBT) on heart rate variability (HRV) in people with depression and/or anxiety disorders: A systematic review and meta-analysis · Positive with limitations
Summary prepared with AI assistance. Source verification does not imply an independent replication or a clinician's endorsement. Read our review method.