Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.
Participants receiving infrared laser stimulation performed better on selected attention and memory tasks. This small study explored healthy volunteers, not treatment of a diagnosed condition.
Barrett DW, Gonzalez-Lima F.
Neuroscience · Publication date: 2012-11-27
Added to site: 2026-09-09
DOI: 10.1016/j.neuroscience.2012.11.016
Publication date recorded by Europe PMC; online and issue dates may differ.
- Modalities
- PBM
- Clinical focus
- Cognition
- Population
- Healthy volunteers
- Sample
- 40 volunteers: 20 treated, 20 controls
- Intervention / method
- Forehead infrared laser stimulation
- Comparator
- Placebo control
Clinician summary
The authors reported improvements in vigilance reaction time and delayed-match-to-sample performance, with favorable self-reported affect at two weeks.
How to interpret the findings
Small sample and limited follow-up. Results cannot establish disease-treatment efficacy or be generalized to all red-light devices.
Equipment and disclosures
The abstract identifies a CG-5000 laser.
Funding and competing-interest disclosures were not verified from the reviewed abstract.
Related evidence
Compare findings from the same clinical area, including mixed results.
- Multimodal evidence associated with 20Hz rTMS in AD: neuroaxonal injury reduction, neural oscillatory rebalancing, and multilayer network integration · Positive with limitations
- Synergistic modulation of the dorsolateral prefrontal cortex and precuneus enhances cognitive recovery in mild cognitive impairment: A multimodal neuroimaging study · Positive with limitations
- The potential of infra-low frequency neurofeedback training in peak performance: The first double-blinded placebo-controlled longitudinal study in healthy adults. · Neutral / negative
- Clinical efficacy of non-pharmacological interventions on cognitive improvement in patients with mild to moderate Alzheimer's disease: A systematic review and Bayesian network meta-analysis. · Positive with limitations
- Personalized Brain Stimulation based on Brain Oscillations: A Systematic Review of MEG- and EEG-informed Transcranial Alternating Current Stimulation (tACS). · Positive with limitations
- Bilateral Angular Gyrus 810-nm Transcranial Near-Infrared Stimulation Reshapes Brain Network: Ameliorate Alzheimer's Disease Cognitive Deficits. · Positive with limitations
- Effects and safety of repetitive transcranial magnetic stimulation on cognitive outcomes in mild cognitive impairment: a systematic review and meta-analysis · Positive with limitations
- Multimodal Neurorehabilitation Including Auditory EEG Neurofeedback: A Proof of Concept Tested After Resection of a Giant Olfactory Groove Meningioma · Positive with limitations
- Temporal-Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial. · Positive with limitations
Summary prepared with AI assistance. Source verification does not imply an independent replication or a clinician's endorsement. Read our review method.