Interictal electric source imaging with open-source software and routine low-density electroencephalography: A systematic comparison of four inverse methods in drug-resistant epilepsy.
Source imaging helped localize the presumed seizure-generating region in a selected surgical population. This evaluates assessment, not neurofeedback treatment.
Parra-Díaz P, Valls-Carbó A, Niso G, Beltrán-Corbellini Á, Román IS, Gil-Nagel A, Masjuan J, Delgado RT.
Epilepsia · Publication date: 2026-09-10
Added to site: 2026-09-12
DOI: 10.1002/epi.70481
First-publication date in the authoritative indexed record.
- Modalities
- EEG, sLORETA
- Clinical focus
- Epilepsy, Source imaging
- Population
- Drug-resistant epilepsy with at least one year of postoperative follow-up
- Sample
- 79 surgical patients
- Intervention / method
- Four inverse methods at two spike time points
- Comparator
- Postsurgical cavity concordance and Engel I outcome
Clinician summary
Half-rising-phase sLORETA achieved 81.0% accuracy, 82.5% sensitivity and 77.3% specificity, outperforming minimum norm. Timing affected performance.
How to interpret the findings
Retrospective surgical selection and a composite reference standard limit generalization. Findings do not establish screening accuracy in unselected patients or improved clinical outcomes.
Equipment and disclosures
Brainstorm open-source software; routine low-density EEG.
Funding and conflicts were not verified from the abstract.
Related evidence
Compare findings from the same clinical area, including mixed results.
- Bridging Temporal and Spatial Scales: Contemporary Advances in EEG-fMRI Integration With a Focus on Epilepsy. · Positive with limitations
- Predicting levetiracetam neuropsychiatric adverse effects using graph-theoretical electroencephalographic network metrics in drug-naive focal epilepsy: A multicenter longitudinal study. · Positive with limitations
- Conditional spatial classification of expert-confirmed interictal epileptiform discharge epochs: An EEG-ECG ablation and SHAP analysis. · Positive with limitations
Summary prepared with AI assistance. Source verification does not imply an independent replication or a clinician's endorsement. Read our review method.