Photobiomodulation therapy and the regulation of excitation-inhibition balance in neurological and psychiatric disorders: Mechanistic and translational perspectives.

This review explores how light might affect brain-cell energy, blood supply and inflammation. Promising mechanisms are not proof of treatment benefit.

Bersotti FM, Alves G, Generoso VA, Neiva GS, Soares LL, Nunes GS, Daghastanli NA, Kato Prates IT, Takada SH.
Neuroscience · Publication date: 2026-09-11
Added to site: 2026-09-14
DOI: 10.1016/j.neuroscience.2026.09.014

First electronic publication date from authoritative index; indexing date may differ.

Modalities

PBM

Clinical focus

Brain health

Population

Experimental models and early clinical studies across neurological and psychiatric conditions

Sample

No pooled denominator in the abstract

Intervention / method

Red and near-infrared photobiomodulation

Comparator

Varied underlying studies; no pooled comparison

Clinician summary

The authors connect mitochondrial, vascular and immune pathways with excitation-inhibition regulation. This is a narrative synthesis, not a treatment-selection validation.

How to interpret the findings

No pooled effect or systematic risk-of-bias analysis is reported in the abstract. Does not establish a dose or EEG-guided prescription.

Equipment and disclosures

Equipment details were not verified from the reviewed abstract.

Funding and conflicts were not verified from the reviewed abstract.

Related evidence

Compare findings from the same clinical area, including mixed results.

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