Concurrent TMS-EEG to characterise interhemispheric signal propagation over the motor and prefrontal regions: An independent replication of GABAB receptor mechanisms

Published October 16, 2026. The study independently replicated a drug-sensitive TMS-EEG signal over the motor region, while the same effect was not significant over the prefrontal region. This is a mechanistic methods result, not a clinical test or treatment outcome.

Zhou J, He Y, Jin C, Yang C, Han Y, Wang Y, Zhen Z, Huang Z, Shi S, Che X, He J.
PLOS One · Publication date: 2026-10-16
Added to site: 2026-10-19
DOI: 10.1371/journal.pone.0360250

Published October 16, 2026. Added to Neurofeedback.com October 19, 2026.

Modalities

TMS-EEG, EEG, TMS

Clinical focus

Interhemispheric signal propagation, GABAB modulation, Independent replication

Population

Adult research participants

Sample

29 participants

Intervention / method

Participants received oral baclofen, a GABAB receptor agonist, or placebo. Single-pulse TMS-EEG measured interhemispheric signal propagation in motor and dorsolateral-prefrontal regions before and after dosing.

Comparator

Baclofen versus placebo, with pre-dose and post-dose TMS-EEG measurement

Clinician summary

Baclofen reduced motor-region interhemispheric signal propagation relative to placebo (P = .037), consistent with increased inhibition. The dorsolateral-prefrontal effect was not significant (P = .186), supporting regional specificity rather than a universal GABAB-sensitive measure.

How to interpret the findings

Small mechanistic sample and a regional null result. The experiment examined acute pharmacological modulation, not diagnosis, prognosis or treatment benefit. Allocation, adverse events, effect sizes beyond P values and complete equipment detail were unavailable in the checked abstract.

Equipment and disclosures

TMS and EEG system models were not identified in the checked abstract. No BrainMaster attribution.

Crossref lists support from the Zhejiang Provincial Natural Science Foundation of China, the Zhejiang Key Laboratory of Precision Psychiatry and a Zhejiang medical science and technology project. The authors declared no competing interests. No indexed correction, retraction or concern relation appeared in the retained PubMed or Crossref records; this is a bounded check. AI-assisted review.

Related evidence

Compare findings from the same clinical area, including mixed results.