Enhanced neuroprotective effects of combined photobiomodulation and hydrogen inhalation in a mouse model of hypoxic-ischemic brain injury.

Combined treatment preserved movement and reduced neuronal loss more than either approach alone in mice. Human benefit has not been demonstrated by this experiment.

Yu GG, Kim SM, Kim SC, Park GJ, Kim YM, Chai HS, Park HJ, Kim H.
Experimental brain research · Publication date: 2026-09-05
Added to site: 2026-09-12
DOI: 10.1007/s00221-026-07352-4

First-publication date in the authoritative indexed record.

Modalities

PBM

Clinical focus

Brain injury, Preclinical

Population

Mice with induced hypoxic-ischemic brain injury

Sample

Animal count not reported in the abstract

Intervention / method

PBM combined with hydrogen inhalation; outcomes at 24 hours

Comparator

PBM alone and hydrogen inhalation alone

Clinician summary

Acute behavioral and tissue findings accompanied reduced inflammatory and apoptotic signaling. Only the abstract and public publisher disclosures were checked.

How to interpret the findings

Preclinical, 24-hour outcomes; sample size, dosing, allocation and blinding were unavailable in the abstract. No human efficacy, durability or safety inference.

Equipment and disclosures

Device details were not verified from the abstract.

Publisher preview identifies Korean NRF/MSIT funding (RS-2024-00358977); authors declare no financial or personal relationships influencing the study.

Related evidence

Compare findings from the same clinical area, including mixed results.